Joe, this is going to have to be a collaborative effort due to a couple of complications.   SpaceSniffer is able to generate a text report, but believe it or not, it's entirely accessible until you hit the screen where you generate it.  I can't find any way to activate the Export button on that page with a screen reader.

TreeSize Free generates an exported PDF report, which most don't like, but I just found that its actual space analysis report in the program appears to be accessible, so you can go down through it line by line there once its done the scan.  Here's what I've put together as the "tutorial starter" and you'll need to give me feedback regarding what happens after the report is up and you've attempted to read through it to see what's hogging the space.  It could go perfectly smoothly or you could hit bumps.  It's your job to report back about that.
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TreeSize Free Download Page – You can select either the installable version or portable version from the dropdown on that page.  Either will get the information you  need.  There is also a cluster of 3 radio buttons to indicate the region of the world for which you’re downloading:  North America/Europe/Other, followed by the Download Button.

This tutorial will presume you’ve downloaded the portable version (ZIP format) and have already unzipped it to the folder from which you wish to run the program and are sitting in that folder.

1.       Fire up TreeSizeFree.exe.

2.       Hit ALT+S,D [Scan Tab/Ribbon, Select Directory], you will then be presented with your drive options as well as a Select Directory to Scan option at the end of the submenu.  Pick what’s appropriate for what you’re doing.  I will choose a directory for the rest of this tutorial, and that directory will end up being C:\Program Files (x86)\NVDA.  If you use the directory option you will be presented with a typical File Explorer navigation dialog to select the folder you want.  You can, of course, type out the path in the Folder edit box if you know it.  The choice is yours.  As soon as you've selected/typed a folder hit the Select Folder button and the scan begins.

3.       If you keep focus on the TreeSizeFree window it will begin reading out the result of its analysis when it finishes, and for folder that will be very quickly.  What starts the report is the folder or drive level you chose to scan.  Down arrowing will take you through the various subfolders and files associated with it, reading out names, sizes, etc.

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Brian - Windows 10 Pro, 64-Bit, Version 2004, Build 19041  

Always remember that computers are just glorified light bulbs - they rarely fail in continuous use and usually go pop when turned off and on.

        ~ Technician with the username Computer Bloke, on Technibble.com