Any one here could recommend a free and accessible noise cancellation software for Windows 10. Thanks.

Evidently, you want something that will reduce unwanted sound when using your microphone. Did you look at what may already be available on your computer? The following article discusses various ways of reducing noise. One free option is discussed that you have to pay a certain amount per month for if you use it more than a certain amount of time a week, but the amount of free usage may be more than enough for you if it will work on your computer. It appears to require a certain brand of video card, but I don't know why.
https://www.howtogeek.com/670474/how-to-reduce-microphone-background-noise-on-a-pc/

Gene